VKORC1 polymorphisms and complete resistance to Vitamin K antagonists: About two cases.

Ilham Benyamna, Department of Cardiology and Internal Medicine, Inezgane Provincial Hospital, Agadir, Morocco.Follow
Houda El Fissi, Laboratory of Biotechnologies and Valorization of Natural Resources , Biology Department, Faculty of Sciences, Ibn Zohr University , Agadir, Morocco.Follow
Fadoua Bouzid, Department of Environment and Life Sciences, Faculty of Sciences, Ait Melloul, Ibn Zohr University , Agadir, Morocco.Follow
Abdelhamid El Mousadik, Laboratory of Biotechnologies and Valorization of Natural Resources , Biology Department, Faculty of Sciences, Ibn Zohr University , Agadir, Morocco.Follow
Najat Alif, Laboratory of Biotechnologies and Valorization of Natural Resources , Biology Department, Faculty of Sciences, Ibn Zohr University , Agadir, Morocco.Follow

Abstract

Complete resistance to vitamin K antagonists is a rare but serious. It can complicate therapeutic management, especially when direct oral anticoagulants cannot be used. Some single mutations in the VKORC1 gene have been identified in patients partially or completely resistant to vitamin K antagonists. We report the cases of two women in their fifties who presented an unexplained peripheral venous thrombosis. The aetiological assessment did not show any abnormalities. Genetic testing showed that both patients had the VKORC1 5417GG genotype. The VKORC1 3673 genotype was GG in case 1 and GA in case 2. The two patients showed complete resistance to vitamin K antagonists which required a change in treatment with favourable outcomes. Our goal is to offer optimal care guided by a literature review.

Recommended Citation

Benyamna, Ilham; El Fissi, Houda; Bouzid, Fadoua; El Mousadik, Abdelhamid; and Alif, Najat (2024) "VKORC1 polymorphisms and complete resistance to Vitamin K antagonists: About two cases.," BioMedicine: Vol. 14 : Iss. 1 , Article 6.
DOI: 10.37796/2211-8039.1434