Impacts of DNA ligase I genotypes on Taiwan Parkinson’s disease

Chao-Hsuan Chen, Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan
Wen-Shin Chang, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
Chia-Wen Tsai, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
Da-Tian Bau, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
Shih-Wei Hsu, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
Kun-Ting Hong, National Defense Medical University, Taipei, Taiwan
Chon-Haw Tsai, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
Fuu-Jen Tsai, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
Ming-Kuei Lu, Graduate Institute of Biomedical Sciences, China Medical University, Taichung, TaiwanFollow
Jai-Sing Yang, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, TaiwanFollow

Abstract

Introduction: Genetic polymorphisms in DNA repair pathways can modulate

DNA repair capacity and influence susceptibility to aging-related disorders, including Parkinson’s disease (PD). This study evaluated the association between the DNA ligase I rs20579 polymorphism and PD risk.

Materials and Methods: Genotyping of DNA ligase I rs20579 was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in

123 PD patients and 492 age- and sex-matched controls of Taiwanese Han ethnicity.

Associations between rs20579 genotypes and PD risk were analyzed.

Results: Among controls, the genotype distribution of rs20579 was 78.7% GG, 19.3% AG, and 2.0% AA, compared with 75.6%, 21.1%, and 3.3% among PD cases, respectively (p for trend=0.6290). No significant differences were observed in the prevalence of AG (p=0.6939) or AA (p=0.4908) genotypes between cases and controls. Allelic analysis showed a non-significant increase in PD risk for A allele carriers (OR=1.21, 95% CI=0.80–1.83, p=0.4189). Stratified analysis revealed no significant genotype differences among males. In females, the AA genotype was associated with a borderline increased risk of PD (OR=1.86, 95% CI=1.00–3.47, p=0.0526).

Conclusion: In this Taiwanese Han cohort, the DNA ligase I rs20579 A allele may be a genetic marker of increased PD susceptibility in females. Further studies in larger, independent populations are warranted to confirm its clinical relevance.

Recommended Citation

Chen, Chao-Hsuan; Chang, Wen-Shin; Tsai, Chia-Wen; Bau, Da-Tian; Hsu, Shih-Wei; Hong, Kun-Ting; Tsai, Chon-Haw; Tsai, Fuu-Jen; Lu, Ming-Kuei; and Yang, Jai-Sing (2026) "Impacts of DNA ligase I genotypes on Taiwan Parkinson’s disease," BioMedicine: Vol. 16 : Iss. 2 , Article 2.
DOI: 10.37796/2211-8039.1681